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A fat-regulating enzyme could hold the key to obesity, diabetes, cancer, other diseases

But scientists at Rutgers University-New Brunswick have now found that getting rid of the enzyme entirely can increase the risk of cancer, inflammation and other ills. Their findings were published online in the  Journal of Biological Chemistry  last month. "The goal of our lab is to understand how we can tweak and control this enzyme," said George M. Carman, Board of Governors professor in the Department of Food Science in the School of Environmental and Biological Sciences. "For years, we have been trying to find out how to fine-tune the enzyme's activity so it's not too active, and creating too much fat, but it's active enough to keep the body healthy." The enzyme was discovered in 1957 and Gil-Soo Han, research assistant professor in the Rutgers Center for Lipid Research, discovered the gene encoding the enzyme in 2006. The enzyme determines whether the body's phosphatidic acid will be used to create fat, or create the lipids in cell membr...

People with schizophrenia are dying younger

The study was published today in  CMAJ  ( Canadian Medical Association Journal ). "Our study shows that individuals with schizophrenia are not benefiting from public health and health care interventions to the same degree as individuals without schizophrenia," says Dr. Paul Kurdyak, senior author, CAMH and ICES Scientist and Director of Health Outcomes with the Medical Psychiatry Alliance (MPA), which supported the study. "As health care providers, it is our responsibility to work together across our health care system to provide these patients with better, integrated physical and mental health care. By not doing so, there are dire, tragic consequences and shortened lives." Researchers studied all deaths during the 20-year period between 1993 and 2012 in Ontario and examined the deaths annually. They identified all people with schizophrenia and categorized the deaths as occurring among those with and without schizophrenia. The study showed that individuals w...

Cells programmed like computers to fight disease

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This can be a determine exhibiting RNA sequence of command. Credit score: Professor Jaramillo/College of Warwick Led by Professor Alfonso Jaramillo within the Faculty of Life Sciences, new analysis has found widespread molecule -- ribonucleic acid (RNA), which is produced abundantly by people, vegetation and animals -- could be genetically engineered to permit scientists to program the actions of a cell. In addition to combating illness and damage in people, scientists may harness this system to regulate plant cells and reverse environmental and agricultural points, making vegetation extra resilient to illness and pests. RNAs carry data between protein and DNA in cells, and Professor Jaramillo has proved that these molecules could be produce...